Marmin, a Compound from Aegle Marmelos Corr., Relaxes the Ovalbumin- Induced Contraction of Trachea
نویسندگان
چکیده
In the previous study, marmin isolated from Aegle marmelos Correa has been evaluated for its effects on the contraction of guinea pig tracheal chain (GPT) induced by histamine and compound 48/80. Marmin inhibited the histamine-induced contraction in competitive manner. Marmin also successfully inhibited compound 48/80-induced contraction. In the study, we investigated the effect of marmin on immunologically induced GPT contraction. In addition, we also investigated the effect of marmin to GPT relaxation contracted by a single concentration of histamine. In present study, marmin succeeded to inhibit the contraction of GPT induced immunologically by 3 μg/mL ovalbumin. In addition, marmin also relaxed the precontraction of GPT induced by 3 x 10-5 M histamine. The value of pD2 of marmin was 4.42±0.02.
منابع مشابه
Aegle marmelos Extract Can Enhance Memory in Rats
Diabetes mellitus is associated with disturbances of learning and memory and cognitive functioning. Aegle marmelos Corr. from Rutaceae family, is widely used in Iranian folk medicine for the treatment of diabetes mellitus. It decreases blood glucose level by improving glucose tolerance and also has lipid-lowering and antioxidant properties. Considering the beneficial antidiabetic...
متن کاملInteraction of active compounds from Aegle marmelos CORREA with histamine-1 receptor
UNLABELLED The aim of this study is to determine the affinity of six active compounds of Aegle Marmelos Correa, they are (E, R)-Marmin, skimmianine, (S)-aegeline, aurapten, zeorin, and dustanin as antihistamines in histamine H1 receptor in comparison to cetirizin, diphenhydramine and chlorpheniramine as ligands comparison. Previously, in the in vitro study marmin obviously antagonized the hista...
متن کاملThe Effect of Chronic Administration of Aegle Marmelos Seed Extract on Learning and Memory in Diabetic Rats
Objective(s) Diabetes mellitus is associated with disturbances of learning and memory and cognitive functioning. Aegle marmelos Corr. from Rutaceae family is widely used in Iranian folk medicine for the treatment of diabetes mellitus. Considering the beneficial antidiabetic and antioxidant potential of A. marmelos, this study was conducted to evaluate the effect of oral administration of A. ma...
متن کاملProtective Effects of Aegle Marmelos Extract Againest Doxyrubicin Induced Genotoxicity in Swiss Albino Mice
In the present study the protective effects of Aegle mamelos fruit extract AMF were carried out in somatic cells of mice against doxyrubicin induced genotoxicity. Three different doses of Aegle Marmelos fruit extract were tested for the antimutagenicity using the micronucleus test in bone marrow cells of mice. The test compound doxyrubicin higher dose 16 mg/kg was injected intrapertioneally pri...
متن کاملPhytochemical and pharmacological screening of in vivo anti-inflammatory activity of Aegle marmelos(L.) Corr. Serr
The aim of this study is to evaluate anti-inflammatory activity and to determine phytochemical constituent of ethanolic leaf extract of Aegle marmelos(L.) Corr. Serr.. Plant materials are collected from Punjab. Ethanolic extract was screened for different phytochemical constituents. Acute toxicity studies are done according to OECD guidelines. Ethanolic extracts were screened for anti-inflammat...
متن کامل